Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur
Asian Journal of Medicine and Health,
Background: Congenital infections are transmissible in utero and it can lead to serious foetal outcomes. These infections can be early detected in pregnant women with bad obstetric history for better foetal outcomes.
Aim of the Study was to evaluate the association of TORCH infection with bad obstetric history among pregnant women.
Study Design: Observational and comparative study
Place and Duration of Study: Central laboratory, Department of Microbiology, SMS Medical College, Jaipur between April 2020 and September 2021.
Methodology: 260 blood samples of pregnant women (130 with bad obstetric history and 130 pregnant women without bad obstetric history) were collected. and tested for the presence of IgM and IgG antibodies against Toxoplasma gondii, Rubella virus, Cytomegalovirus by Chemiluminescence and Herpes simplex virus using ELISA kits.
Results: Overall TORCH IgM seropositivity in high-risk pregnant women was 17.19%. In pregnant women with bad obstetric history, IgM Seropositivity for Toxoplasma gondii was 3.84% (P value .02), rubella 2.34% (P value .30), Cytomegalovirus 5.47% (P value .08), and 6.25% (P value .56) for Herpes-1 and 2 infections and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 16.41% (P value .001), 93.75% (P value .11), 98.44% (P value .55), 48.44% (P value .53) respectively. In pregnant women without bad obstetric history, IgM and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 0/0.77%, 0.76/97.69%, 1.53/99.23% and 4.61/44.62% respectively. The average age of the study population was 27.13 years.
Conclusion: As TORCH infections are transmissible in-utero in all the stages of pregnancy and contributes in neonatal and infant deaths, so early diagnosis and appropriate interventions necessary which help in proper management of the pregnant women.
- Pregnant women
- bad obstetric history
- congenital infections
- IgM and IgG seropositivity
- TORCH infections
- TORCH screening.
How to Cite
Marzoqi AHM, Kadhim RA, Janabi DKF, Hussein HJ, Taee ZMA. Seroprevalence study of IgG and IgM Antibodies to Toxoplasma, Rubella, Cytomegalovirus, Chlamydia trachomatis and Herpes simplex II in Pregnancy women in Babylon Province. Journal of Biology, Agriculture and Healthcare. 2012;2(10):159-164.
Lamichhane B, Pudasaini B, Upadhyay B, Sharma M, Khanal SP. Prevalence of serum antibodies to TORCH infections among the women of child bearing age visiting National Public Health Laboratory, Teku. Nepal Journal of Science and Technology. 2014; 15(2):85-90.
Mohammad EAK, Salman YJ. Study of TORCH infections in women with Bad Obstetric History (BOH) in Kirkuk city. Int. J. Curr. Microbiol. App. Sci. 2014;3(10):700-709.
Shah A, Muhammad H, Farooqi N, Gul N, Khan A, Nabi G et al. Association of TORCH Agents with Spontaneous Abortion in Patients with Bad Obstetric History. World J. Zool., 2005;10(4):291-294.
Suryawanshi R, Deo S, Suryawanshi M. Serological study of TORCH infections in women with high delivery risk factors. Journal of Evolution of Medical and Dental Sciences 2014;3(40):10194-10201.
Leung K, Hon K, Yeung A, Leung A, Man E. Congenital infections in Hong Kong: an overview of TORCH. Hong Kong Medical Journal. 2020;26(4):323-330.
Abdulla SF, Al-Omar LS, Mukhlis FA. Prevalence of TORCH agents in complicated pregnancy. Iraqi J Med Sci. 2003;2(3):14-20.
Condorelli F, Scalia G, Stivala A, Costanzo M, Adragna A, Franceschino C et al. Seroprevalence to some torch agents in a sicilian female population of fertile age. European Journal of Epidemiology 1993;9(3):341-343
Rajani M. Serological profile of TORCH Infection Among Antenatal Women at a Tertiary Care Center in North India, J Pure Appl Microbiol 2018;12(4):2305-2311.
Guddy K, Pant P, Shama J, Pokharel B, Singh M, Pradhan N. Association of TORCH antibodies in women with spontaneous abortions. Health Renaissance. 2015;12(2):124-129.
Makhijani S, Raut S. Seroprevalence of TORCH infection and adverse reproductive outcome in women with bad obstetric history. Indian Journal of Obstetrics and Gynaecology Research 2021;8(1):49–52.
Konikkara KP, Manjiyil IJ, Narayanan VA et al. Seroprevalence of torch infections in pregnant women attending antenatal clinic in a tertiary care hospital. J. Evolution Med. Dent. Sci. 2019;8(39):2958-2962.
Tiwari S, Arora BS, Diwan R. TORCH IgM seroprevalence in women with abortions as adverse reproductive outcome in current pregnancy. Int J Res Med Sci. 2016;4(3):784-788.
MS Sadik, H Fatima, K Jamil, C Patil. Study of TORCH profile in patients with bad obstetric history. Biology and Medicine 2012;4(2):95-101.
Yadav RK, Maity S, Saha S. A review on TORCH: groups of congenital infection during pregnancy. Journal of Scientific and Innovative Research 2014;3(2):258-264.
Poudyal A, Poudyal N and Khanal B. Seroprevalence of TORCH infection – A Laboratory Profile. International Journal of Biomedical Research 2018;09(04):154-157.
Parikh J, Chaudhary A, Kavathia GU, Goswami YS. Prevalence of Serum Antibodies to Torch Infection in Women with Bad Obstetric History Attending Tertiary Care Hospital, Gujrat. IOSR Journal of Dental and Medical Sciences 2016;15(5):14-16.
Prasoona K, Srinadh B, Sunitha T, Sujatha M, Deepika M, Vijaya Lakshmi B et al. Seroprevalence and Influence of Torch Infections in High-Risk Pregnant Women: A Large Study from South India. The Journal of Obstetrics and Gynecology of India. 2014;65(5):301-309.
Rasti S, Ghasemi F, Abdoli A, Piroozmand A, Mousavi S, Fakhrie-Kashan Z. ToRCH “co-infections” are associated with increased risk of abortion in pregnant women. Congenital Anomalies. 2016;56(2):73-78.
R. Lakshmi Kumari K. Seroprevalence of TORCH Infections in Pregnant Women with Bad Obstetric History in and around Kakinada Town, India. International Journal of Current Microbiology and Applied Sciences. 2017;6(4):1899-1906
Pradhan S. Epidemiological and serological profiles of TORCH infection in pregnancy. Journal of Pathology of Nepal. 2015;5(9):705-708
Kaur R, Gupta R, Nair D, Kakkar M and KD Mathur. Screening for TORCH infections in Pregnant Women: A Report from Delhi. Southeast Asian J Trop Med Public Health 1999; 30(2):284-286.
Turbadkar D, Mathur M, Rele M. SEROPREVALENCE OF TORCH INFECTION IN BAD OBSTETRIC HISTORY. Indian Journal of Medical Microbiology. 2003;21(2):108-110.
Padmawathy M, Mangala Gowri, Malini J, Umapathy BL, Navaneeth BV, Mohit Bhatia, Shruthi Harle. Seroprevalence of TORCH infection & adverse reproductive outcome in current pregnancy with bad obstetric history. J Clin Biomed Sci 2013;3(2):62-71.
Swapna C Senan; Anitha C; Sarala Gopalakrishnan; Dinesh Roy D. ROLE OF TORCH INFECTION, OXIDATIVE STRESS AND SOMATIC DNA DAMAGE IN HIGH-RISK PREGNANT WOMEN LEADING TO CONGENITAL ANOMALIES. European Journal of Molecular & Clinical Medicine. 2020;7(09):1125-1132.
Jasim, M., Majeed, H.A., Al-Ezzy,A. Performance of Serological Diagnosis of TORCH Agents in Aborted versus non aborted Women of Waset province in Iraq. Tikrit Medical Journal 2011;17(2):141-147.
Manjunathachar HV, Singh KN, Chouksey V, Kumar R, Sharma RK, Barde PV. Prevalence of Torch Infections and Its Associated Poor Outcome in High-Risk Pregnant Women of Central India: Time to Think for Prevention Strategies. Indian Journal of Medical Microbiology 2020;38(3-4):379-384.
Greenough A. The TORCH screen and intrauterine infections. Arch Dis Child Fetal Neonatal Ed. 1994;70(3):163-165.
Gong Z, Luo L, Xiao H. Preliminary study on ToRCH epidemic laws in Wuhan region. Chinese Journal of Experimental and Clinical Virology 1999;13(2):139-141.
Chung M, Shin C, Lee J. TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea. Korean Journal of Pediatrics. 2018;61(4):114.
Kumar R, Binnani A, Shyoran S. Seroprevalance of TORCH infections in pregnant women with bad obstetric history in and around Bikaner, Northern Western Rajasthan. Sch.J. App.Med. Sci,2018;6(5):2018-2023.
Chopra S, Arora U, Aggarwal A. Prevalence of IgM Antibodies to Toxoplasma, Rubella and Cytomegalovirus Infection During pregnancy. J K Science 2004;6(4):190-192.
Sen MR, Shukla BN and Banerjee T. Prevalence of serum antibodies to TORCH infection in and around Varanasi, Northern India. J.Clin Diagn Res. 2012;6(9):1483-1485.
Ghazi H, Telmesani A, Mahomed M. TORCH Agents in Pregnant Saudi Women. Medical Principles and Practice. 2002;11(4):180-182.
Nirmal K, Saha R, Ramachandran V, Maroof Khan A. TORCH infection in antenatal women: A 5-year hospital-based study. Eastern Journal of Medical Sciences. 2017;2(4):54-57.
Manjunathachar HV, Singh KN, Chouksey V, Kumar R, Sharma RK. Prevalence of Torch Infections and Its Associated Poor Outcome in High-Risk Pregnant Women of Central India: Time to Think for Prevention Strategies. Indian J Med Microbiol 2020;38(3 & 4):379-384.
Faldu B, Panchal P, Patel H, Patel. A Study for seropositivity for TORCH infection in women with bad obstetric history. International Journal of Advance Research 2015;3(8):1324-1332.
Newton E. Diagnosis of Perinatal TORCH Infections. Clinical Obstetrics and Gynaecology, 1999;42(1):59-70.
Sebastian D, Zuhara KF and Sekaran K. Influence of TORCH infection in first trimester miscarriage in the Malabar region Kerala. African Journal of Microbiology Research. 2008;2,56-59.
Saxena N, Manju Lal, Mittal G, Priya. Is screening of TORCH worthwhile in women with bad obstetric history: An observational study from Himalayan Hospital. Int J Biol Med Res.2015;6(3):5158-5161.
Fatima N, Sami H, Nabeela N, Khan P, Khan H. Seroprevalence of TORCH Infection in Patients with Bad Obstetric History in and around Aligarh, Northern India. International Journal of Scientific Research. 2012;3(7):432-434.
Ghazi HO, Telmesani AM, Mahomed MF. TORCH agent in pregnant Saudi women. Med. Prince. Pract. 2002;11(4):180-182.
Obaid H, Juma S. TORCH Screening Test in Pregnant Women of Kirkuk City. Al-Mustansiriyah Journal of Science. 2017;27(5):17.
Thapliyal N, Shukla PK, Kumar B, Upadhyay S, Jain G. TORCH infection in women with bad obstetric history- A pilot study in Kumaon region. Indian J Pathol Microbiol 2005; 48(4):551-553
Tamer G, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clinical & Investigative Medicine. 2009;32(1):43:E43-7.
Nabi S, Wasey A, Haider K, Khan A, Hoque M. Seroprevalence of TORCH antibody in pregnant women. Journal of Armed Forces Medical College, Bangladesh. 2013;8(1):35-39.
Shrivastava G, Bhatambare GS, Patel KB. Seroprevalence of toxoplasma, rubella, CMV and HSV infection in pregnant women in central India. Int J Health Syst Disaster Manage, 2014;2:166-169.
Sahu S, Pradhan S, Nayak L. Seroprevalence of TORCH infection among pregnant women. International Journal of Community Medicine and Public Health. 2019;6(5):2189-2194.
Baghel S, Inamdar S. TORCH Infection and Its Influence on High-risk Pregnancy. J South Asian Feder Obs Gynae 2020;12(6):376-382.
Surpam RB, Kamlakar UP, Khadse RK, Qazi MS, Jalgaonkar SV. Serological study for TORCH infections in women with bad obstetric history. J Obstet Gynecol India, 2006; 56(1):41-43
Kumari N, Morris N, Dutta R. Is Screening of TORCH Worthwhile in Women with Bad Obstetric History: An Observation from Eastern Nepal. Journal of Health, Population and Nutrition. 2011;29(1):77-80.
Guddy K, Pant P, Shama J, Pokharel B, Singh M, Pradhan N. Association of TORCH antibodies in women with spontaneous abortions. Health Renaissance. 2015;12(2),124-129.
Mustafa M, Sultana Q, Begum N, Nooreen M, Fatima S. A Study of Torch Screening in Women with Bad Obstetric History. International Journal of Current Microbiology and Applied Sciences. 2018;7(04):2155-2160.
Josheghani SB, Moniri R, Taheri FB, Sadat S, Heidarzadeh Z. The Prevalence of Serum antibodies in TORCH Infections during the First Trimester of Pregnancy in Kashan, Iran. Iranian Journal of Neonatology. 2015;6 (1): 8-12.
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